Preparation and the Efficacy Evaluation of an Oil-emulsion Inactivated Vaccine Against Novel Duck Reovirus Disease
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摘要: 鸭出血性坏死性肝炎是新型鸭呼肠孤病毒引起的危害养鸭业的一种新传染病。为防制该病,本研究以NDRV JM85株为种毒研制成油佐剂灭活苗,并通过免疫血清学检测及攻毒保护试验评价疫苗效果。结果表明,该疫苗安全性好,免疫原性强,麻鸭二免后28d产生较高的中和抗体,并能维持较长时间。种番鸭免疫后的子代雏番鸭具有一定的母源抗体,能够抵抗强毒的感染,可用于防制鸭新型呼肠孤病毒病。Abstract: Novel Duck Reovirus(NDRV) was the pathogen of duck Hemorrhagic-necrotic hepatitis, which was an epizootic disease of ducklings, has been prevailed in China since 2005. In order to control the disease, one oil-emulsion inactivated vaccine had been developed by NDRV JM85 and the potential protective efficacy was assessed. The study indicated that this vaccine could induce strong immune responses after secondary immunization of sheldrake and the titers of neutralizing antibodies reach the peak at 28d post-immunization.84d post-immunization, the neutralizing antibodies still maintain at a high level. Baby Muscovy ducks born from mothers vaccinated with the oil-emulsion vaccine were protected successfully against NDRV infection, during the first week of life when the risk of this disease was highest. These results showed that the vaccine had a good prospect for against novel duck reovirus disease.
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