Abstract: Immune stimulating complex(ISCOMs) is an efficient mucosal delivery system which can induce non-specific immune response.Bovine serum albumin(BSA) was incorporated into ISCOMs(BSA-ISCOMs).Pseudosciaena crocea took diets containing BSA-ISCOMs for 10 d,while the control group took diets containing PBS.At the 15th and 30th day after oral completion,serum was collected for non-specific immune parameters analysis.The results showed that at 15th day after oral completion,SOD,C3 and total protein of the fish feeding BSA-ISCOMs were significantly higher than those of the control fish(P<0.05),and interferon γ of the former was higher than that of the latter,but not significantly(P>0.05),while lysozyme of the former was significantly lower than that of the latter(P<0.05).At 30th day after oral completion,these parameters except lysozyme of the experimental group were not significantly different from the control group(P>0.05).The results of the challenge with Vibrio vulnificus at 30th day after oral completion showed that the cumulative mortality of the control and the experimental group was 100% and 26.7%,respectively,and the relative percent survival(RPS) was 73.3%.So this study indicated that BSA-ISCOMs can induce the immune response and improve the disease resistance of Pseudosciaena crocea.