Abstract: 2400healthy Epinephelus coioides with an average weight of 76.9g were randomly divided into six groups-commercial pellets feed 1(No.1),commercial pellets feed 2(No.2),commercial pellets feed 3(No.3),commercial powder feed 1(No.4),commercial powder feed 2(No.5)and coarse fish(No.6,as control),and fed with the experimental diets and coarse fish for 60d.Effects of different feed and coarse fish on growth,feed conversion ratio and immunity of Epinephelus coioides were examined.The results showed that the group of coarse fish had the highest growth rate,followed by soft pellet feed group,and the last is hard pellet feed group.The group of coarse fish and commercial powder feed 2(No.5)had the lowest feed conversion ratio.The soft pellet feed group had the highest protein efficiency.No.6,No.5 had significant effect on the non-specific immunity of Epinephelus coioides(P<0.05).Based on calculating weight gain,feed conversion rate and immunity,coarse fish can be completely replaced by formula feed for grouper(Epinephelus coioides)without affecting the growth performance.