Abstract: To test the effects of different doses and fertilizer regimes of molybdenum on leaf size, economic characters and conventional chemical composition of flue-cured tobacco, field experiments were conducted in Changshun area.The results showed that the molybdenum could increase the the blade size, yield and production of tobacco, and reduce the proportion of variegated tobacco significantly;and molybdenum fertilization could increase the content of the potassium and reduce the content of the nicotine within tobacco leaves.The effect of foliar spraying on the leaves or combination of watering the root and spraying were much better than that of watering root once when transplanting.