Abstract: The effects of planting density and different NPK on the yield of Quandou 7were studied by the design of orthogonal rotational regression combinatorial design.The results showed that the order of affecting yield of Quandou 7was nitrogenous fertilizer>phosphate fertilizer>potassium fertilizer>planting density.The optimal cultural methods for yields above 2 147.25kg·hm2 was as followed:planting density was(3.548-3.782)×105 plants,nitrogenous fertilizer was 79.02-88.71kg·hm-2,phosphate fertilizer was 438.75-484.5kg·hm-2 and potassium fertilizer was 64.17-75.27kg·hm-2.