Abstract: Negative factors in environment including abiotic stress and biotic stress and so on are toxic for rice(Oryza sativa L.)growth and development.Thus rice has developed many mechanisms of stress resistance by themselves for their healthy growth.Multidrug and toxic compound extrusion(MATE)transporters,which involve detoxication of toxic compounds of cells,present a new large family protein in plants.They play an important role of detoxication for plant cell.In order to provide new thoughts and theoretical basis of rice stress resistance,the characteristics for MATE transporters,molecular mechanism and their biological function were stated in the paper.Meanwhile,the role of MATE transporters for stress resistance in rice was also set forth.