Abstract: Using 311-A optimal fitting saturated regressive design, the regression model for ‘Shenliangyou 5814'rice rotated after Tobacco was established with the factors in transplanting density, nitrogen rate and potassium rate.The results indicated that the effects of single factor on rice yield revealed in order of nitrogen rate >transplanting density> potassium rate.The interaction effect between two factors were in order as transplanting density and nitrogen rate > transplanting density and potassium rate > nitrogen rate and potassium rate.The optimum combination in factors was simulated with computer optimization, which was in transplanting density 210000hills·hm-2, potassium rate (K2O) 138.1kg·hm-2 and nitrogen rate (N) 143.4kg·hm-2 for the highest rice yield in 8 908.18kg·hm-2.