Abstract: Gerbera jamesonii is one of five major cut flowers in the world.It has a high economic value.Its planting area continues to expand.At the same time, the disease problem is also becoming increasingly serious.Root rot is one of the main diseases on G.jamesonii that has widely spread in recent years causing heavy economic losses.This paper reviews recent developments on the molecular biology of the plant-pathogen interactions relating to the disease's mechanism and the host plant's natural defense against the disease.Prospect of applying molecular breeding, as well as other potentially applicable approaches, for the disease prevention and control is discussed.