Abstract: Four factors and 5levels of a secondary general rotation design was applied to carry out an optimization experimentation for the maize cultivation.The relationships among the cultivation, crop yield, planting density and NPK fertilization were obtained for Nongda 108 with a mathematic model.The four agronomic factors that affected the grain yield were:potash > nitrogenous fertilizer > phosphate > planting density.The optimized agronomic conditions included a planting density of 59 000-62 500strains·hm-2, and the fertilizations of urea at 341.33-374.10kg·hm-2, calcium superphosphate at 460.58-554.85kg·hm-2, and potassium sulfate at 234.23-279.23kg·hm-2, which resulted in a grain yield of more than 7 000kg·hm-2.