Abstract: Ninety weaned piglets Duroc×Landrace×Yorkshire,average body weight(11.2±0.8)kgwere selected and divided into group 1(control group,basic diet),group 2(basic diet added with antibiotics),group 3(basic diet added with xylo-oligosaccharide),group 4(basic diet added with probiotics)and group 5(basic diet added with probiotics and xylo-oligosaccharide).Each group had 3repeats,to observe the effect of probiotics and xylo-oligosaccharide on growth performance and enteric microbial in weaned piglets.The results showed that thoct compared with control,the average daily gain was significantly increased in group 2,3,4and group 5(P<0.05)and the highest was observed in group 5,showing significantly increase than group 2;feed conversion rate,serum urea N and E.coli in jejunum were significantly decreased(P<0.05)in group 2,3,4,5and the lowest of them was observed in group 5.Serum IgG and IgM were higher in group 3,4,5than group 2and control(P<0.05),and the highest levels of IgG and IgM was obtained in group 5.Lactic acid bacteria in jejunum were higher in group3,4,5than group 2and control(P<0.05)and the highest was obtained in group 5.The results indicated that based diet added individually or combination with probiotics and xylo-oligosaccharide can improve the growth performance,microbial population status and immune function of weaned piglets.