Abstract: There is strong heterosis between indica and japonica subspecies of rice(Oryza sativa L.),but the utilization of the inter-subspecies heterosis is seriously restricted by sterility problem of hybrid F1 of indica and japonicarice.Application of rice wide-compatibility resources and genes is considered to be a key to overcome the hybrid sterility.In this paper,we summarized recent advances in genetics research of rice wide-compatibility,and the mapping,cloning and molecular mechanisms of the related genes in recent years,meanwhile the problems and solutions for the utilization of the inter-subspecies heterosis in rice breeding were also discussed.