Abstract: To analyze the structural characteristics and properties of Konjac Glucomannan (KGM) as drug carrier. Methods KGM/CMC-Na, KGM/SAA and KGM/CMC-Na/SAA drug carriers were prepared by complex method, and were analyzed with the porosity and electron microscopy. Infrared spectroscopy was used to analyze its stability. Results The combination of KGM/SAA and KGM/CMC-Na can play a synergistic effect; KGM/SAA is more stable than KGM/CMC-Na and KGM/SAA/CMC-Na; KGM/SAA is higher porosity, and its drug capacities is 73%; the particle size of KGM/SAA drug carrier is about 0.31~0.38mm, and uniform distribution. Conclusion KGM/SAA is the most suitable as drug carriers in three samples.