Abstract: Various commercially available herbicides were evaluated for weed control on sweet potato fields. The phytotoxicity of 15 herbicides was firstly tested in a chamber on sweet potato seedlings by foliar spray. Then, the 10 that showed no or low toxic effect on the seedlings were subjected to a field test. It was found that the applications of 25% rimsulfuron WDG at 90 g·hm^-2, 330 g·L^-1 pendimethalin EC at 1 800 mL·hm^-2, 900 g·L^-1 acetochlor EC at 1 050 mL·hm^-2, and 960 g·L^-1 s-metolachlor EC at 1 200 mL·hm^-2 were more effective in weed control than the others. The selected herbicides applied at the levels reduced more than 82% on weight of fresh weeds in 50 ds after spraying. In the subsequent multi-location field test, the foliar application of acetochlor or s-metolachlor exhibited superior weed control efficacy with safety. Consequently, it was deemed applicable on sweet potato fields.