Objective  Acute toxicities of commonly applied drugs on juvenile Pseudogobio vaillanti were determined for safe disease control in aquaculture ponds.

  Method  Using a static bioassay method, toxicities of 8 antimicrobial agents, i.e., ncluded potassium permanganate, copper sulfate, dipterex, chlorine dioxide, 20% concentrated glutaraldehyde solution, 45% benzalkonium bromide solution, 10% povidone iodine solution, and salt, on juvenile P. vaillanti were studied. The tank water temperature was maintained within 21.3 to 23.5 ℃. Toxicity accumulation coefficient (MAC) was also employed as index for the evaluation.

  Result  The agents displayed toxicities on the fish ranking from the strongest to the weakest as: copper sulfate＞chlorine dioxide＞potassium permanganate＞45% benzalkonium bromide solution＞dipterex＞20% concentrated glutaraldehyde solution＞10% povidone iodine solution＞salt, with the safety mass concentrations (SC) of 0.019, 0.061, 0.346, 0.701, 1.377, 2.674, 6.906, and 910.6 mg·L⁻¹, respectively. However, no consistent pattern on MAC of the agents could be obtained as it varied with the duration of treatment.

  Conclusion  It appeared that most of the commonly used drugs could be safely applied on juvenile P. vaillanti for the aquaculture, but special cautions would be required on the use of salt, potassium permanganate, and copper sulfate.