Abstract: In response to heavy metal stress plants alter the root exudate secretion in ways depending on the plant species and type of heavy metals, among other factors. This article reviews the published literature on the organic acids, amino acids, and soluble sugars in root exudates and their roles in the chemistry and physiology of the plants under varieties of heavy metal stresses. The referred material and documents concerning the tolerance and adaptability of plants to heavy metals as well as the response mechanisms involving the key chemicals would provide a concise and update information for the scientists interested in the field of study.