Abstract: Tobacco bactetial wilt(Pseudomonas solanacearum),a major tobacco disease in Fujian province,general occures from the southen to northen of Fujian during late April and early May.If the climate condition is favorable for it from middle to the end of May,the disease would become greatly prevalent,especially in Spring tobacco,The occurrence and damage of the disease were closely related to cultivars,cropping system,cultivation practics and topography.The experimental results showed that,on tobacco bacterial wilt control,effects of 90%Yishuangqing soluble powder was over 80%superior to sulphurate streptomycin(10 million units).