Abstract: A study was conducted to optimize the cultivation of the high-yield, early-mature hybrid rice, Jinyou 2155, based on three factors: planting density(X1),quantity of nitrogen(X2)and leaf age at transplantation(X3). The regression models for the three factors affecting the rice yield were established. The experimental results reveal that X2 and X3 exerted significant influences on the yield, and that there was a significant positive correlation between X1 and X3, as well as a significant negative correlation between X2 and X3. The overall effect on yield was found to be in the order of X3X2 X1. After a simulated screening and optimization by computer,4.3-5.2 leaves for transplanting at the density of 196 100-261 300 hills perhm2 with a nitrogen application of 140.1-182.6 kghm-2 was recommended for the cultivation. The experimental results of the combined application of N, P, K and organic fertilizers indicated that increased N, P and K could raise the yield to some extend, while the increased organic fertilization promoted the growth by increasing effective panicles on the plant. On the other hand, the chemical nitrogen fertilization ought to be limited to avoid a negative effect on yield.