Abstract: A "3414" fertilizer experiment was carried out in Jiangbei farm of five fields to determine the yield and economic effect of nitrogen, phosphorus and potassium fertilization on mid-season rice. The result showed that the effect of fertilization on mid-season rice yield increase is obvious: the effect of N fertilization on mid-season rice yield and economic benefit was largest,the next was P, and K fertilization was the smallest. The highest in yield of N,P and K were 695.1-2 414.7 kg穐m-2, and which were 8.6%-37.8% higher than contro1.The net income of N, P and K were 1 011.2-3 563.5 Yuan穐m-2, respectively. According to fertilizer effect, N, P2O5 and K2O application rate to get the highest profit were 180-200 kg穐m-2, P2O5 55-60 kg穐m-2, and K2O 50-60 kg穐m-2, respectively.