Abstract: The cadmium pollution in medium materials of Agaricus Blazei Murrill was investigated and analyzed in main production area of Fujian Province,and the effect of cadmium pollution in medium materials on fruit body was studied.The result showed that the cadmium content of CaH2(PO4)2 was higher than that of dry cow dung,that of rice straw was the lowest.Cadmium was absorbed by mycelium and accumulated in fruit body,consequently.The content of cadmium in medium composition was positively correlated to the content cadmium in fruit body.Regulation equation(y=-4.01+94.01x1+54.32x2+679.46x3) indicated the relationship among cadmium content in fruit body(y) and the cadmium content of rice straw(x1),cow dung(x2),CaH2(PO4)2(x3) in cultivation compositions.The value of leading factor was CaH2(PO4)2.Meanwhile,important effects of cow dung in medium materials on the yield of fruit body and the amount of amino acids,providing theoretic base for the cultivation standardization of Agaricus Blazei Murrill.