Abstract: In order to compare the efficaeies of Diclazuril, Rumensin and Robenidine against rabbit coccidiosis, rabbits (n=50) were randomly grouped into uninfected and unmedicated treatment (Ⅰ), infected and unmedicated treatment (Ⅱ), Rumensin treatment(Ⅲ), Diclazuril treatment (Ⅳ) and Robenidine treatment(Ⅴ).TreatmentⅢ,ⅣandⅤwere artificially infected with rabbit coccidian oocysts (1×105) after being fed with drugs for three days.The results indicated that Diclazuril was the same effective as Rumensin and more effective than Robenidine in reducing oocyst output and controlling Eimeria spp.lesion and Coccidosis mortality, and increasing body-weight gain and feed effieency; the effectiveness of Robenidine was poor and had little difference from that of infected and unmedicated.It was concluded that Robenidine was not fit to be applied continually and solely, new highly effective medicine should be used or medicines should be used alternately and combinatively against rabbit coccidiosis.