Abstract: This paper reviewed the research progress on nutrient requirements of protein (or amino acid), lipid (fat acid, phospolipids, cholesterol etc) and carbohydrate for mud crab, Scylla serrata, broodstock nutrition, and the key technology of Scylla serrata healthy culture in recent years.Healthy culture is the future direction for Scylla serrata culture, it is an integrative technique measure of aquaculture science and technology innovation, the technical links bind, restrict and supplement each other during the whole culture process.