Abstract: Quatic product safety has become an important public health problem, the most prominent is the drug residue problem. Safe aquatic feed is the base for producing aquatic products, and the quality of aquatic products (such as fish meal) as a raw material for feed production would affect the safety of feed. These two aspects complement each other. This paper illustrates the relationship of drug residue between aquatic feed and product , the causes and the hazards of drug residues, puts forward countermeasures and points out it is a long and arduous task to deal with safety issue in aquatic feed and products. For practitioners, they should be aware of the causes and hazards of drug residues, and take appropriate measures to minimize the harm. For administrators, they should accelerate setting and improving the policies and regulations of industry ,and strengthen supervision.