Study on Antigen Correlation of Different PRV Strains

CHENG Xiao-xia; CHE Yong-liang; WANG Shao; XIAO Shi-feng; ZHU Xiao-li; CHEN Shi-long; LIN Feng-qiang; CHEN Shao-ying; ZHOU Lun-jiang

doi:10.19303/j.issn.1008-0384.2018.04.001

Volume 33 Issue 4

Mar. 2019

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Fujian Journal of Agricultural Sciences > 2018 > 33(4): 337-340. > DOI: 10.19303/j.issn.1008-0384.2018.04.001

CHENG Xiao-xia, CHE Yong-liang, WANG Shao, XIAO Shi-feng, ZHU Xiao-li, CHEN Shi-long, LIN Feng-qiang, CHEN Shao-ying, ZHOU Lun-jiang. Study on Antigen Correlation of Different PRV Strains[J]. Fujian Journal of Agricultural Sciences, 2018, 33(4): 337-340. DOI: 10.19303/j.issn.1008-0384.2018.04.001

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Study on Antigen Correlation of Different PRV Strains

Institute of Animal Husbandry and Veterinary Medicine/Fujian Animal Diseases Control Technology Development Center, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China

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Received Date: February 02, 2018
Revised Date: March 17, 2018

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Abstract

Antigenicity difference among strains of pseudorabies virus (PRV) and potential of developing a vaccine to prevent new PRV from occurring were studied. Four PRV strains (i.e., PRV FB, FA, Bartha-K61 and prevalent PRV-FJ2012) and hyperimmune serums were used for the analysis by a cross neutralization test. The possibility of using PRV-FB to develop a vaccine was evaluated by a challenge test. The neutralization titers of hyperimmune serum for rabbit anti-FB, anti-FA, anti-Bartha-K61 and anti-FJ2012 were 1:54, 1:91, 1:91, and 1:215, respectively. The correlation coefficients between FB and FA, FB and FJ2012, and FA and FJ2012 were all greater than 0.8. However, those between Bartha-K61 and FA, Bartha-K61 and FB, and Bartha-K61 and FJ2012 were lower than 0.4. The results indicated that the relationship between the antigens of FB and FJ2012 was closer than that of Bartha-K61 and FJ2012. The viral challenge test showed that FB could prevent PRV-FJ2012 at a rate of 100%.These conclusion indicated FB strain was a vaccine candidate strain to prevent the new PRV strain(FJ2012 strain).
- pseudorabies virus (PRV),
- FA strain,
- FB strain,
- Bartha-K61 strain,
- FJ2012 strain,
- antigen correlation,
- immune protection

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