Selection of Attenuated Vaccine Strain of Duck Paramyxovirus

CHENG Xiao-xia; CHEN Shao-ying; ZHU Xiao-li; LIN Feng-qiang; CHEN Shi-long; WANG Shao; LI Zhao-long

Volume 27 Issue 5

Jul. 2012

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Article Navigation > Fujian Journal of Agricultural Sciences > 2012 > 27(5): 457-460

CHENG Xiao-xia, CHEN Shao-ying, ZHU Xiao-li, LIN Feng-qiang, CHEN Shi-long, WANG Shao, LI Zhao-long. Selection of Attenuated Vaccine Strain of Duck Paramyxovirus[J]. Fujian Journal of Agricultural Sciences, 2012, 27(5): 457-460.

Citation:

CHENG Xiao-xia, CHEN Shao-ying, ZHU Xiao-li, LIN Feng-qiang, CHEN Shi-long, WANG Shao, LI Zhao-long. Selection of Attenuated Vaccine Strain of Duck Paramyxovirus[J]. Fujian Journal of Agricultural Sciences, 2012, 27(5): 457-460.

Citation:

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Selection of Attenuated Vaccine Strain of Duck Paramyxovirus

1.
Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou, Fujian 350013, China;
2.
Animal Diseases Control Technology Development Center, Fuzhou, Fujian 350013, China

Received Date: 2012-04-18
Rev Recd Date: 2012-04-29
Publish Date: 2012-05-30

Abstract

Abstract

An attenuated vaccine strain of Duck Paramyxovirus(DPMVa) was selected and obtained by passage serial within SPF chicken embryo fibroblast(CEF), and some biological property of it were detemined. The DPMVa was non-pathogenic to Muscovy ducks without maternal antibody; and was non-viulence through five serial passages in one-day-old Muscovy ducks; TCID50 to CEF stable between 10-6.0~10-6.5·(0.1 mL)-1. The protection rate of the attenuated strain was above 90% when challenged with a virulent strain of DPMV 7 days after vaccination. The results indicated that attenuated vaccine strain had excellent safety, effective immunogenicity and genetic stability, which could be used as a vaccine against DPMV.
- duck paramyxovirus,
- attenuated vaccine strain,
- selection

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References(3)

References

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