Safety and immunogenicity of the inactivated Porcine reproductive and respiratory syndrome virus vaccines

This study was designed to examine the safety and immunogenicity of two inactivated vaccines of porcine reproductive and respiratory syndrome virus(PRRSV,Fuzhou-01).The vaccines were inactivated by formalin and concentrated.The oil emulsionor IMS1312 adjuvant-inactivated vaccines contained approximately 108 TCID50(median tissue culture infections dose) PRRSV.Thirty 25-day-old PRRSV-free pigs were randomly divided into five groups to test the safety and efficacy of the vaccines.The results indicated that the PRRSV antibody was detected in 14 days after the initial vaccination,reached the peak value in 14 days after the second vaccination,and was maintained at the ratio of 1:320 in 180 days after the initial vaccination.Both vaccines were stabilized at 4℃ for 12 months and proved to be safe for post-weaning pigs.